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FLASH GENE
Symbol SRC contributors: mct/npt/pgu - updated : 19-06-2017
HGNC name v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
HGNC id 11283
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
in a small proportion of endometrial carcinoma and colon cancer
tumoral   deletion    
in some leukemia
tumoral     --over  
in some cancers
constitutional     --over  
results in the tyrosine phosphorylation and cytoplasmic localization of RUNX3
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivestomach
RUNX3 can be relocalized in the nucleus by an SRC inhibitor, in gastric cancers, providing an additional rationale for developing SRC inhibitors as anti-cancer drugs
cancerreproductivebreast
RUNX3 can be relocalized in the nucleus by an SRC inhibitor, in breast cancers, providing an additional rationale for developing SRC inhibitors as anti-cancer drugs
immunologyinflammatory 
both SRC and NOS3 inhibition may be important therapeutic targets to prevent or limit vascular inflammation
ANIMAL & CELL MODELS
  • despite normal phosphorylation, sperm from cSrc null mice display a severe reduction in forward motility, and are unable to fertilize