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FLASH GENE
Symbol SMURF2 contributors: mct - updated : 14-03-2018
HGNC name SMAD specific E3 ubiquitin protein ligase 2
HGNC id 16809
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
during replicative senescence in response to telomere shortening, and induces senescence when expressed adventitiously in early passage or telomerase-immortalized fibroblasts
tumoral     --over  
correlates with poor prognosis in patients with esophageal squamous cell carcinoma
constitutional     --over  
in human osteoarthritis (OA) tissue
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • adult Col2a1-Smurf2 mice have an osteoarthritis-like phenotype in knee joints