Symbol
| SMURF2
| contributors: mct - updated : 14-03-2018
|
HGNC name
| SMAD specific E3 ubiquitin protein ligase 2
|
HGNC id
| 16809
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
during replicative senescence in response to telomere shortening, and induces senescence when expressed adventitiously in early passage or telomerase-immortalized fibroblasts | tumoral
|  
|  
| --over
|  
|
correlates with poor prognosis in patients with esophageal squamous cell carcinoma | constitutional
|  
|  
| --over
|  
|
in human osteoarthritis (OA) tissue | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| adult Col2a1-Smurf2 mice have an osteoarthritis-like phenotype in knee joints |