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FLASH GENE

Symbol

C1GALT1

contributors: mct - updated : 14-11-2018

HGNC name	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
HGNC id	24337

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   promotes breast cancer cell growth through MUC1-C signaling pathway

Susceptibility

to IgA nephropathy (IGAN)

Variant & Polymorphism other	variants of C1GALT1 associated with the genetic susceptibility to IgA nephropathy
	polymorphisms in the C1GALT1 gene were associated with genetic susceptibility to Uyghur IgAN

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas targeting C1GALT1 could be a promising approach for ovarian cancer therapy cancer reproductive breast potential of C1GALT1 as a target of novel therapeutic agent development in breast cancer

ANIMAL & CELL MODELS

C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes