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FLASH GENE
Symbol C1GALT1 contributors: mct - updated : 14-11-2018
HGNC name core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
HGNC id 24337
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
promotes breast cancer cell growth through MUC1-C signaling pathway
Susceptibility
  • to IgA nephropathy (IGAN)
  • Variant & Polymorphism other
  • variants of C1GALT1 associated with the genetic susceptibility to IgA nephropathy
  • polymorphisms in the C1GALT1 gene were associated with genetic susceptibility to Uyghur IgAN
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    targeting C1GALT1 could be a promising approach for ovarian cancer therapy
    cancerreproductivebreast
    potential of C1GALT1 as a target of novel therapeutic agent development in breast cancer
    ANIMAL & CELL MODELS
  • C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes