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FLASH GENE
Symbol SOCS4 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 4
HGNC id 19392
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in Alzheimer disease brains
tumoral     --over  
significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
constitutional germinal mutation      
in autoimmune disorder
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • mice lacking functional Socs4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs