Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

FERMT2

contributors: mct/pgu - updated : 27-06-2017

HGNC name	fermitin family homolog 2 (Drosophila)
HGNC id	15767

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast tumors constitutional         resulting in early embryonic lethality tumoral         in leiomyomas compared with normal myometrium tumoral     --low   greatly decreased in leiomyosarcomas tumoral     --over   in malignant mesothelioma, and heightened expression of Kindlin-2 might contribute to tumor progression

Susceptibility

to sporadic Alzheimer disease (SAD)

Variant & Polymorphism SNP	rs17125944 in FERMT2 is associated with sporadic AD (SAD) patients

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate targeting the FERMT2-GLI1 feedback loop may facilitate the killing of prostate cancer cells

ANIMAL & CELL MODELS