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FLASH GENE
Symbol FERMT2 contributors: mct/pgu - updated : 27-06-2017
HGNC name fermitin family homolog 2 (Drosophila)
HGNC id 15767
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast tumors
constitutional        
resulting in early embryonic lethality
tumoral        
in leiomyomas compared with normal myometrium
tumoral     --low  
greatly decreased in leiomyosarcomas
tumoral     --over  
in malignant mesothelioma, and heightened expression of Kindlin-2 might contribute to tumor progression
Susceptibility to sporadic Alzheimer disease (SAD)
Variant & Polymorphism SNP
  • rs17125944 in FERMT2 is associated with sporadic AD (SAD) patients
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the FERMT2-GLI1 feedback loop may facilitate the killing of prostate cancer cells
    ANIMAL & CELL MODELS