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FLASH GENE
Symbol DDX43 contributors: mct - updated : 15-10-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
HGNC id 18677
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
by promoter hypomethylation and DDX43 hypomethylation may be a favorable prognostic factor in acute myeloid leukemia
tumoral     --over  
hypomethylation of the DDX43 promoter directly correlates with its expression in both CML cell lines and patients and is associated with advanced disease and poor outcome
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerskin 
cancer therapies targeting DDX43 helicase may have broad applications for treating malignant melanoma
ANIMAL & CELL MODELS