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FLASH GENE
Symbol RAD9A contributors: mct/pgu - updated : 30-06-2015
HGNC name RAD9 homolog A (S. pombe)
HGNC id 9827
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
leads to drastic reduction of the RAD9A–MLH1 interaction and MMR activity and to tumors
tumoral   amplification    
in prostate cancer cells due at least in part to aberrant methylation or gene amplification
tumoral     --over  
in prostate cancer cell lines
Susceptibility
Variant & Polymorphism
Candidate gene Rad9 protein level can thus provide a biomarker for advanced prostate cancer and is causally related to the disease
Marker
Therapy target
ANIMAL & CELL MODELS