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FLASH GENE
Symbol SCRIB contributors: mct/pgu - updated : 24-08-2016
HGNC name scribbled homolog (Drosophila)
HGNC id 30377
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
deregulation strongly correlated with poor survival in human prostate cancer
tumoral     --low  
and changed localization of SCRIB were associated with clinical stage, histopathological differentiation, and lymph node metastasis in endometrial cancer
Susceptibility to craniorachischisis (CRN)
Variant & Polymorphism other
  • missense variants in SCRIB may represent a cause of CRN
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Scrib1-deficient mice exhibit enhanced learning and memory abilities and impaired social behavior, two features relevant to autistic spectrum disorders
  • in Drosophila, loss of Scribbled (Scrib), a cell polarity regulator and neoplastic tumor suppressor, results in impaired Hippo pathway signaling in the epithelial tissues of both the eye and wing imaginal disc