Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SCRIB

contributors: mct/pgu - updated : 24-08-2016

HGNC name	scribbled homolog (Drosophila)
HGNC id	30377

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   deregulation strongly correlated with poor survival in human prostate cancer tumoral     --low   and changed localization of SCRIB were associated with clinical stage, histopathological differentiation, and lymph node metastasis in endometrial cancer

Susceptibility

to craniorachischisis (CRN)

Variant & Polymorphism other	missense variants in SCRIB may represent a cause of CRN

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Scrib1-deficient mice exhibit enhanced learning and memory abilities and impaired social behavior, two features relevant to autistic spectrum disorders
	in Drosophila, loss of Scribbled (Scrib), a cell polarity regulator and neoplastic tumor suppressor, results in impaired Hippo pathway signaling in the epithelial tissues of both the eye and wing imaginal disc