Symbol
| KDM3A
| contributors: mct - updated : 01-09-2016
|
HGNC name
| lysine (K)-specific demethylase 3A
|
HGNC id
| 20815
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor | tumoral
|  
|  
| --over
|  
|
in Ewing Sarcoma | tumoral
|  
|  
| --over
|  
|
in human bladder carcinomas | tumoral
|  
|  
| --over
|  
|
in renal cell carcinoma | constitutional
|  
|  
| --over
|  
|
significantly increased in smooth muscle cells upon hypoxia treatment | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| can act as useful biomarker for predicting male infertility | Therapy target
| loss of KDM3A is sufficient to reduce tumor growth |
| |
| Jhdm2a-deficient mice exhibit post-meitoic chromatin condensation defects and JHDM2A directly binds to and controls the expression of transition nuclear protein Tnp1 and protamine genes, suggesting that JHDM2A is essential for spermatogenesis |