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FLASH GENE
Symbol MAML2 contributors: mct/npt/pgu - updated : 08-01-2018
HGNC name mastermind-like 2 (Drosophila)
HGNC id 16259
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with CRTC1 in t(11;19) (q21;p13) in mucoepidermoid salivary gland carcinoma with a significantly lower risk of local recurrence, metastases, or tumor-related death compared to fusion-negative patients
tumoral fusion      
with CRTC1 in clear cell variants of cutaneous hidradenomas
tumoral fusion      
fusion genes CRTC1-MAML2 and CRTC3-MAML2 may play a similar role in the development of mucoepidermoid carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • CRTC1/3-MAML2 fusion gene analysis can be a useful method for diagnosing hidradenoma
  • detection of the CRTC1/MAML2 fusion transcript provides useful information for mucoepidermoid carcinoma (MEC) diagnosis but is not associated with differences in survival outcomes
  • molecular detection of MAML2 rearrangement combined with FLT1 may be of important clinical value for Primary pulmonary mucoepidermoid carcinoma (PMEC)
  • Therapy target
    ANIMAL & CELL MODELS