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FLASH GENE
Symbol NECTIN4 contributors: mct - updated : 20-12-2016
HGNC name nectin cell adhesion molecule 4
HGNC id 19688
ASSOCIATED DISORDERS
corresponding disease(s) EDCS2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
transactivated in a majority of NSCLC (Takano 2009)
tumoral        
histological and serological tumor-associated marker for breast carcinoma (Fabre-Lafay 2007)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • high level of expression is associated with poor prognosis in NSCLC (Takano 2009)
  • might play a significant role in lung carcinogenesis and should be a new candidate serum and tissue biomarker as well as a therapeutic target (Takano 2009)
  • marker of disease progression and levels correlating with the number of metastasis in breast carcinomas (Fabre-Lafay 2007)
  • ANIMAL & CELL MODELS