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Symbol IL2RA contributors: mct - updated : 07-09-2017
HGNC name interleukin 2 receptor, alpha
HGNC id 6008
corresponding disease(s) IMD41
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in leukemia stem cells and correlated with adverse outcomes in young patients with acute myeloid leukemia (AML)
  • to IDDM (type 1 diabetes)
  • to rheumatoid arthritis (RA)
  • to multiple sclerosis (MS)
  • to primary sclerosing cholangitis (PSC)
  • Variant & Polymorphism SNP , other
  • snp increasing the risk of IDDM (type 1 diabetes)
  • role of the IL2RA gene on MS susceptibility
  • IL2RA-rs2104286 is the only known genetic variant associated with both joint destruction and RA-persistence
  • Treg impairment may play a role in the immune dysregulation observed in PSC, and reduced Treg numbers in patients with PSC are associated with polymorphisms in the IL2RA gene
  • CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset
  • Candidate gene
  • is an independent prognostic factor in elderly AML patients
  • can be a potent marker of disease activity and therapeutic effects in patients with Kawasaki disease
  • IL2RA expression is a specific and relatively sensitive marker for the identification of Ph+ B acute lymphoblastic leukemia (B-ALL) in the pediatric population
  • Therapy target
  • murine podocytes express the Il2ra, and activation through the Il2ra results in podocyte injury