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FLASH GENE
Symbol WIF1 contributors: mct - updated : 23-01-2017
HGNC name WNT inhibitory factor 1
HGNC id 18081
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with HMGA2 in the salivary gland pleomorphic adenoma
tumoral     --low  
in salivary gland pleomorphic adenoma in progression
tumoral     --low  
in mesothelioma 72-fold compared to normal tissue, and WIF1 promoter methylation is a common event in mesothelioma
tumoral     --low  
in 76p100 of examined osteosarcoma cases, with promoter methylation (
tumoral     --low  
is frequently downregulated or silenced by promoter methylation in the carcinogenesis of Oral submucous fibrosis (OSF)
tumoral     --low  
downregulated by promoter methylation and is an important mechanism of aberrant WNT/CTNNB1 pathway activation in astrocytoma pathogenesis
tumoral     --low  
by epigenetic gene silencing is an important mechanism of WNT activation in cervical oncogenesis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbone 
reexpression of WIF-1 in WIF-1-deficient osteosarcoma represents a potential novel treatment and preventive strategy
cancerreproductiveuterus
potent drug target in cervical cancer treatment
cancerdigestiveoesophagus
HOTAIR/WIF1 axis represented a novel therapeutic target in patients with esophageal squamous cell carcinoma (ESCC)
ANIMAL & CELL MODELS