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FLASH GENE
Symbol WIPF1 contributors: mct/npt - updated : 13-06-2015
HGNC name WAS/WASL interacting protein family, member 1
HGNC id 12736
ASSOCIATED DISORDERS
corresponding disease(s) WASP2
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
immunologyimmunodeficiency 
A WAS-binding WIPF1-derived peptide stabilizes WAS in cells from XLT patients with missense mutations that disrupt WIPF1 binding, and corrects their T-cell actin cytoskeleton defect
immunologyinflammatory 
disruption of WIPF1 binding to actin could be of therapeutic value in T cell-driven inflammatory diseases.
ANIMAL & CELL MODELS
  • Wip(-/-) murine hippocampal neurons exhibit enlargement of somas as well as overgrowth of neuritic and dendritic branches that are more evident in early developmental stages