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FLASH GENE
Symbol USP28 contributors: mct - updated : 03-11-2014
HGNC name ubiquitin specific peptidase 28
HGNC id 12625
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colon and breast carcinoma
tumoral     --over  
correlated with KDM1A upregulation in multiple cancer cell lines and breast tumor samples
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivecolon
inhibition of the enzymatic activity of USP28 may be a potential target for cancer therapy
ANIMAL & CELL MODELS
  • mice lacking Usp28 had no apparent adverse phenotypes, but exhibited reduced intestinal proliferation and impaired differentiation of secretory lineage cells