Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

USP28

contributors: mct - updated : 03-11-2014

HGNC name	ubiquitin specific peptidase 28
HGNC id	12625

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon and breast carcinoma tumoral     --over   correlated with KDM1A upregulation in multiple cancer cell lines and breast tumor samples

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon inhibition of the enzymatic activity of USP28 may be a potential target for cancer therapy

ANIMAL & CELL MODELS

mice lacking Usp28 had no apparent adverse phenotypes, but exhibited reduced intestinal proliferation and impaired differentiation of secretory lineage cells