Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TXNIP contributors: mct - updated : 23-10-2016
HGNC name thioredoxin interacting protein
HGNC id 16952
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in diabetes and has deleterious effects on pancreatic beta-cells and the cardiovascular system
constitutional     --over  
is critical to regulating energy expenditure and fuel use during the extreme hypometabolic state of torpor
constitutional     --low  
in IBD (inflammatory bowel disease) patients suggesting that modulation of redox signaling may be an important therapeutic target
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
therapeutic use of small molecular inhibitors to reactivate TXNIP expression for cancer treatment
neurosensorialvisualdegenerative
targeting TXNIP expression is a potential therapeutic target for retinal neurodegenerative disease
diabetetype 2 
potential target to ameliorate blinding ocular complications of diabetic retinopathy
ANIMAL & CELL MODELS