Symbol
| SMARCE1
| contributors: mct - updated : 10-05-2019
|
HGNC name
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
|
HGNC id
| 11109
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in AR-dependent prostatic adenocarcinoma cells | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| putative marker of metastatic potential that could be leveraged for therapeutic intervention | |
predictive marker of endometrial carcinoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | reproductive | ovary | |
may be a target for ovarian cancer therapy | cancer | reproductive | prostate | |
blockade of AR-SMARCE1 interaction is a novel means to target agonist-induced AR function in prostate cancer, and provide the first evidence that abrogation of SWI/SNF function can be developed as a point of therapeutic intervention in prostate cancer | cancer | reproductive | breast | |
targeting SMARCE1 could represent a new way to effectively inhibit the action of ESR1 in breast cancer |
| | |
| Smarce1 is overexpressed in the hippocampus but not in the kidney of tau deficient mice |