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FLASH GENE
Symbol SMARCE1 contributors: mct - updated : 10-05-2019
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
HGNC id 11109
ASSOCIATED DISORDERS
corresponding disease(s) CSSSCE1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in AR-dependent prostatic adenocarcinoma cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • putative marker of metastatic potential that could be leveraged for therapeutic intervention
  • predictive marker of endometrial carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be a target for ovarian cancer therapy
    cancerreproductiveprostate
    blockade of AR-SMARCE1 interaction is a novel means to target agonist-induced AR function in prostate cancer, and provide the first evidence that abrogation of SWI/SNF function can be developed as a point of therapeutic intervention in prostate cancer
    cancerreproductivebreast
    targeting SMARCE1 could represent a new way to effectively inhibit the action of ESR1 in breast cancer
    ANIMAL & CELL MODELS
    Smarce1 is overexpressed in the hippocampus but not in the kidney of tau deficient mice