Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTGES contributors: mct - updated : 08-10-2012
HGNC name prostaglandin E synthase
HGNC id 9599
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
more abundantly in ruptured cerebral aneurysms than in nonruptured
constitutional     --over  
in Alzheimer disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
inhibition of PTGES is an alternative therapeutic target for colorectal and possibly other cancers.
ANIMAL & CELL MODELS
  • deletion of Ptges in mice attenuates neointimal hyperplasia after vascular injury, in part by regulating tenascin-C expression
  • mice deficient in mPges-1 have shown significantly reduced effect on hypertension, thrombosis, and myocardial damage