Symbol
| PTGES
| contributors: mct - updated : 08-10-2012
|
HGNC name
| prostaglandin E synthase
|
HGNC id
| 9599
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
more abundantly in ruptured cerebral aneurysms than in nonruptured | constitutional
|  
|  
| --over
|  
|
in Alzheimer disease  | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | |  |
inhibition of PTGES is an alternative therapeutic target for colorectal and possibly other cancers. |
| | | |
| deletion of Ptges in mice attenuates neointimal hyperplasia after vascular injury, in part by regulating tenascin-C expression  | |
mice deficient in mPges-1 have shown significantly reduced effect on hypertension, thrombosis, and myocardial damage  |