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FLASH GENE
Symbol PHIP contributors: mct - updated : 05-01-2016
HGNC name pleckstrin homology domain interacting protein
HGNC id 15673
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
stimulates insulin-like growth factor 1-dependent and -independent proliferation of beta-cells, an event which correlates with transcriptional upregulation of the cyclin D2 promoter and the accumulation of cyclin D2 protein
tumoral       gain of function
promotes melanoma metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is a molecular prognostic marker of melanoma, revealing a significant linkage between PHIP levels and ulceration
  • Therapy target
    ANIMAL & CELL MODELS