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FLASH GENE
Symbol NEK1 contributors: mct - updated : 30-05-2015
HGNC name NIMA (never in mitosis gene a)-related kinase 1
HGNC id 7744
ASSOCIATED DISORDERS
corresponding disease(s) SRPS2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional        
severely reduces cilia number and alters ciliar morphology
constitutional       loss of function
Nek1 deficiency leads to disordered kidney maturation, and cysts throughout the nephron
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • mutated Nek1 display progressive polycystic kidney disease
  • Nek1 is the primary protein inactivated in kat2J mouse models of PKD