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FLASH GENE
Symbol TRAF4 contributors: mct/npt/pgu - updated : 21-11-2014
HGNC name TNF receptor-associated factor 4
HGNC id 12034
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in metastatic axillary lymph nodes primary breast cancer
tumoral     --over  
in lung adenocarcinomas
tumoral     --over  
might contribute to breast cancer progression by destabilizing TJs and favoring cell migration
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerlung 
TRAF4 offers a candidate molecular target for lung cancer prevention and therapy
ANIMAL & CELL MODELS
  • TRAF4 deficient mice to display impaired neural tube closure,axial skeleton malformations and tracheal ring disruption
  • TRAF4-deficient mice (TRAF4-KO) exhibit altered locomotion coordination typical of ataxia