Symbol
| TRAF4
| contributors: mct/npt/pgu - updated : 21-11-2014
|
HGNC name
| TNF receptor-associated factor 4
|
HGNC id
| 12034
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| amplification
|  
|  
|
in metastatic axillary lymph nodes primary breast cancer | tumoral
|  
|  
| --over
|  
|
in lung adenocarcinomas | tumoral
|  
|  
| --over
|  
|
might contribute to breast cancer progression by destabilizing TJs and favoring cell migration | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | lung | | |
TRAF4 offers a candidate molecular target for lung cancer prevention and therapy |
| | | |
| TRAF4 deficient mice to display impaired neural tube closure,axial skeleton malformations and tracheal ring disruption | |
TRAF4-deficient mice (TRAF4-KO) exhibit altered locomotion coordination typical of ataxia |