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FLASH GENE
Symbol NCALD contributors: mct - updated : 13-03-2017
HGNC name neurocalcin delta
HGNC id 7655
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
counteract the impaired axonal development of SMN-deficient MNs
tumoral     --over  
of PDIA3, LYAR, NOP14, NCALD and MTSS1 genes in the ovarian cancer with poor prognosis
Susceptibility to diabetic nephropathy
Variant & Polymorphism other
  • polymorphisms in the 3prime UTR in NCALD affect mRNA stability, and confer susceptibility to diabetic nephropathy
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neuromuscularspinal muscular atrophy 
    combinatorial therapy that both elevates SMN and decreases NCALD (by ASO treatment) may provide a full protection, resulting in asymptomatic individuals
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    NCALD downregulation might become an efficient strategy against SMA and other neurodegenerative diseases
    ANIMAL & CELL MODELS
  • Ncald downregulation in the nervous system of SMA mice ameliorates also muscle pathology