Symbol
| KHDRBS1
| contributors: shn - updated : 06-06-2014
|
HGNC name
| KH domain containing, RNA binding, signal transduction associated 1
|
HGNC id
| 18116
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
|  
|  
|  
| loss of function
|
likely can strongly reduce follicle maturation and ovulation, thereby limiting the female fertility potential | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | metastases | | |
blockade of phospho-KHDRBS1 may provide a new avenue for therapeutic inhibition of metastatic cancers |
| | | |
| Sam68-/- females were severely subfertile, and they showed a delay in the age of first pregnancy, increased breeding time for successful pregnancy and yielded smaller litters | |
Sam68(-/-) mice were protected from obesity, insulin resistance, and glucose intolerance induced with a high-fat diet |