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FLASH GENE
Symbol KHDRBS1 contributors: shn - updated : 06-06-2014
HGNC name KH domain containing, RNA binding, signal transduction associated 1
HGNC id 18116
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
likely can strongly reduce follicle maturation and ovulation, thereby limiting the female fertility potential
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancermetastases 
blockade of phospho-KHDRBS1 may provide a new avenue for therapeutic inhibition of metastatic cancers
ANIMAL & CELL MODELS
  • Sam68-/- females were severely subfertile, and they showed a delay in the age of first pregnancy, increased breeding time for successful pregnancy and yielded smaller litters
  • Sam68(-/-) mice were protected from obesity, insulin resistance, and glucose intolerance induced with a high-fat diet