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FLASH GENE
Symbol INCENP contributors: mct/npt - updated : 13-09-2023
HGNC name inner centromere protein antigens 135/155kDa
HGNC id 6058
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
significantly higher nuclear expression in high grade B-cell lymphomas versus low grade ones (Barbanis 2009)
tumoral     --over  
in neuroblastoma, significantly associated with poor prognosis in primary tumors of neuroblastoma patients with high-risk disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbrainglioma/neuroblstoma
targeting INCENP presents a novel strategy to disrupt the activity of chromosomal passenger complex and inhibit neuroblastoma progression
ANIMAL & CELL MODELS