Symbol
| GPRC6A
| contributors: mct - updated : 08-04-2015
|
HGNC name
| G protein-coupled receptor, family C, group 6, member A
|
HGNC id
| 18510
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in prostate cancer cell | |
Variant & Polymorphism
|
| |
Candidate gene
| candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues |
|
GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling |
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | reproductive | prostate | |
molecular target for regulating prostate growth and cancer progression |
| | |
| GPRC6A null (GPRC6A(-/-) mice exhibit multiple metabolic abnormalities including osteopenia | |
loss of GPRC6A retarded the progress and improved survival of a mouse model of prostate cancer |
|
Gprc6A-null mice exhibit a mild metabolic syndrome phenotype characterized by hyperglycemia, decreased serum insulin levels, glucose intolerance, and insulin resistance |