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FLASH GENE
Symbol GPRC6A contributors: mct - updated : 08-04-2015
HGNC name G protein-coupled receptor, family C, group 6, member A
HGNC id 18510
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate cancer cell
Susceptibility
Variant & Polymorphism
Candidate gene
  • candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues
  • GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    molecular target for regulating prostate growth and cancer progression
    ANIMAL & CELL MODELS
  • GPRC6A null (GPRC6A(-/-) mice exhibit multiple metabolic abnormalities including osteopenia
  • loss of GPRC6A retarded the progress and improved survival of a mouse model of prostate cancer
  • Gprc6A-null mice exhibit a mild metabolic syndrome phenotype characterized by hyperglycemia, decreased serum insulin levels, glucose intolerance, and insulin resistance