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FLASH GENE
Symbol HCAR1 contributors: mct - updated : 10-09-2015
HGNC name hydroxycarboxylic acid receptor 1
HGNC id 4532
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
by high fat diet reducing adipose tissue HCAR2 and HCAR1 gene expression
tumoral     --over  
in pancreatic cancer
constitutional     --low  
by inflammation decreasing the expression of HCAR1 in adipose tissue
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascularatheromabrain
HCAR1 antagonism might be a novel therapeutic strategy for the treatment of cerebral ischemia
metabolismlipid 
may be an attractive target for the treatment of dyslipidemia and others metabolic disorders
ANIMAL & CELL MODELS
  • in mice, diet-induced obesity significantly reduced Gpr109a and Gpr81 gene expression in epididymal fat pads
  • ob/ob mice, a mouse model of obesity and type 2 diabetes, demonstrate reduced adipose tissue expression of Gpr81
  • Gpr81 expression was decreased in ob/ob mice, an animal model of type 2 diabetes that is characterized by inflammation