Symbol
| HCAR1
| contributors: mct - updated : 10-09-2015
|
HGNC name
| hydroxycarboxylic acid receptor 1
|
HGNC id
| 4532
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
by high fat diet reducing adipose tissue HCAR2 and HCAR1 gene expression | tumoral
|  
|  
| --over
|  
|
in pancreatic cancer | constitutional
|  
|  
| --low
|  
|
by inflammation decreasing the expression of HCAR1 in adipose tissue | |
Candidate gene
Marker
Therapy target
| |
|
System | Type | Disorder | Pubmed |
cardiovascular | atheroma | brain | |
HCAR1 antagonism might be a novel therapeutic strategy for the treatment of cerebral ischemia | metabolism | lipid | | |
may be an attractive target for the treatment of dyslipidemia and others metabolic disorders |
| | |
| in mice, diet-induced obesity significantly reduced Gpr109a and Gpr81 gene expression in epididymal fat pads | |
ob/ob mice, a mouse model of obesity and type 2 diabetes, demonstrate reduced adipose tissue expression of Gpr81 |
|
Gpr81 expression was decreased in ob/ob mice, an animal model of type 2 diabetes that is characterized by inflammation |