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FLASH GENE
Symbol GPR17 contributors: mct/npt - updated : 19-12-2013
HGNC name G protein-coupled receptor 17
HGNC id 4471
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in demyelinating lesions in the CNS
constitutional     --over  
in multiple sclerosis plaques
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
immunologyautoimmunemultiple sclerosis
inhibiting GPR17 emerges as therapeutic strategy to relieve the oligodendrocyte maturation block and promote myelin repair in MS
neurologyneurodegenerative 
may serve as a potential therapeutic target for CNS myelin repair
neurologyacquired 
target for neurorepair and are particularly relevant to setting up new therapies for traumatic brain injury (TBI) patients
ANIMAL & CELL MODELS
Gpr17 knockout mice showed early onset of oligodendrocyte myelination