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FLASH GENE
Symbol GDF11 contributors: shn - updated : 07-09-2016
HGNC name growth differentiation factor 11
HGNC id 4216
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to orofacial cleft
Variant & Polymorphism other
  • variants in SHH, RORA, MRPL53, ACVR1, and GDF11 may contribute to risk of orofacial clefts
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • homozygous mutant mice carrying a targeted deletion of Gdf11 exhibit anteriorly directed homeotic transformations throughout the axial skeleton and posterior displacement of the hindlimbs
  • Gdf11-/- mice have dramatic anteriorly directed homeotic transformations of the axial skeleton (i.e., posterior regions take a more anterior fate)
  • neuronal differentiation in the spinal cord progresses at a slower rate in Gdf11(-/-) mouse embryos (