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FLASH GENE

Symbol

GDF11

contributors: shn - updated : 07-09-2016

HGNC name	growth differentiation factor 11
HGNC id	4216

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to orofacial cleft

Variant & Polymorphism other	variants in SHH, RORA, MRPL53, ACVR1, and GDF11 may contribute to risk of orofacial clefts

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	homozygous mutant mice carrying a targeted deletion of Gdf11 exhibit anteriorly directed homeotic transformations throughout the axial skeleton and posterior displacement of the hindlimbs
	Gdf11-/- mice have dramatic anteriorly directed homeotic transformations of the axial skeleton (i.e., posterior regions take a more anterior fate)
	neuronal differentiation in the spinal cord progresses at a slower rate in Gdf11(-/-) mouse embryos (