Symbol
| FDPS
| contributors: mct/npt - updated : 08-06-2009
|
HGNC name
| farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
|
HGNC id
| 3631
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
|  
| loss of function
|
in the hepatic tissue of patients with peroxisomal disorders such as Zellweger disease and neonatal adrenoleukodystrophy (Romanelli 2009) | |
Susceptibility
|
to lower BMD in postmenopausal Caucasian women |
Variant & Polymorphism
SNP
| (rs2297480) may be a genetic marker for lower BMD in postmenopausal Caucasian women (Levy 2007) |
|
|
Candidate gene
Marker
Therapy target
| selective target of alendronate in the mevalonate pathway (Bergstrom 2000) |
| | |