Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

EPHA7

contributors: mct - updated : 10-07-2019

HGNC name	EPH receptor A7
HGNC id	3390

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in colorectal cancer, via aberrant 5'CpG island methylation tumoral       loss of function in follicular lymphoma (FL) tumoral     --over   expressed at a substantial level in most human lung cancers and the secreted form of EPHA7 mRNA was found in a fraction of primary lung cancer tissues tumoral     --over   correlates with adverse outcome in primary and recurrent glioblastoma multiforme tumoral     --over   in prostate cancer cells resulted in decreased tumor volume and increased tumor apoptosis in primary tumors tumoral         in several different human tumor types including lymphomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   tumor suppressor with immediate therapeutic potential in follicular lymphoma cancer reproductive prostate receptor phosphorylation of EPHA7, at least in part, suppress PCa tumor malignancy through targeting PI3K/Akt signaling pathways reproduction fertility   effective target for the development of innovative medicines to induce ovulation

ANIMAL & CELL MODELS