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FLASH GENE
Symbol EPHA7 contributors: mct - updated : 10-07-2019
HGNC name EPH receptor A7
HGNC id 3390
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in colorectal cancer, via aberrant 5'CpG island methylation
tumoral       loss of function
in follicular lymphoma (FL)
tumoral     --over  
expressed at a substantial level in most human lung cancers and the secreted form of EPHA7 mRNA was found in a fraction of primary lung cancer tissues
tumoral     --over  
correlates with adverse outcome in primary and recurrent glioblastoma multiforme
tumoral     --over  
in prostate cancer cells resulted in decreased tumor volume and increased tumor apoptosis in primary tumors
tumoral        
in several different human tumor types including lymphomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
tumor suppressor with immediate therapeutic potential in follicular lymphoma
cancerreproductiveprostate
receptor phosphorylation of EPHA7, at least in part, suppress PCa tumor malignancy through targeting PI3K/Akt signaling pathways
reproductionfertility 
effective target for the development of innovative medicines to induce ovulation
ANIMAL & CELL MODELS