Symbol
| DEGS1
| contributors: mct - updated : 27-01-2022
|
HGNC name
| degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
|
HGNC id
| 13709
|
corresponding disease(s)
|
HLD18
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
of DEGS1 or DEGS2 attenuated the dihydroceramide accumulation and increased cell proliferation during hypoxia | constitutional
|  
|  
|  
| loss of function
|
is the cause of a sphingolipid disorder with hypomyelination and degeneration of both the central and peripheral nervous systems | constitutional
|  
|  
| --low
|  
|
specifically decreased in the adipose tissue of obese patients | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
obesity | | | |
is a new potential target to restore adipose tissue function and prevent obesity-associated metabolic disturbances |
| | | |