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FLASH GENE
Symbol DEGS1 contributors: mct - updated : 27-01-2022
HGNC name degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
HGNC id 13709
ASSOCIATED DISORDERS
corresponding disease(s) HLD18
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
of DEGS1 or DEGS2 attenuated the dihydroceramide accumulation and increased cell proliferation during hypoxia
constitutional       loss of function
is the cause of a sphingolipid disorder with hypomyelination and degeneration of both the central and peripheral nervous systems
constitutional     --low  
specifically decreased in the adipose tissue of obese patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
obesity  
is a new potential target to restore adipose tissue function and prevent obesity-associated metabolic disturbances
ANIMAL & CELL MODELS