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FLASH GENE
Symbol CLIC4 contributors: mct/npt - updated : 30-09-2017
HGNC name chloride intracellular channel 4
HGNC id 13518
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in tumor stromal cells stimulates tumor growth (Suh 2007)
constitutional     --other  
aberrant CLIC4 expression may contribute to the vascular pathology of pulmonary arterial hypertension
constitutional     --over  
is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension
constitutional     --low  
enhances autophagy and contributes to mitochondrial and ER stress-induced apoptosis under starvation
tumoral     --over  
of CLIC3, CLIC4 in malignant pleural mesothelioma (MPM) as compared to controls
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation (Suh 2007)
ANIMAL & CELL MODELS