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FLASH GENE
Symbol CLDN18 contributors: mct/npt/pgu - updated : 21-06-2023
HGNC name claudin 18
HGNC id 2039
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers
tumoral     --other  
primarily regulated at the transcriptional level via specific PRKC signaling pathways and modified by DNA methylation
tumoral     --over  
in ulcerative colitis
tumoral     --other  
its expression correlates with poor survival in patients with CRC and is associated with the gastric phenotype
tumoral     --over  
in endocervical gastric-type carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • associated with a better survival in lung adenocarcinoma and had an independent prognostic value and may thus be used in the evaluation of patient prognosis
  • marker for the early carcinogenetic process, is commonly expressed in precursor lesions of pancreatic ductal adenocarcinomas
  • the expression of CLDN7 and the loss of CLDN18 may be independent indicators of a poor prognosis in patients with gastric cancer
  • is likely a promising surrogate marker to separate gastric-type carcinoma (GAS) from other types of endocervical gastric-type carcinoma, including clear cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    (CLDN18.2) is a promising target in Gastric cancer (GC) therapy
    ANIMAL & CELL MODELS
  • Claudin-18 null mice had significantly higher serum IgE levels and increased airway responsiveness following intranasal aspergillus sensitization