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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CKS1B

contributors: mct/ - updated : 26-11-2021

HGNC name	CDC28 protein kinase regulatory subunit 1B
HGNC id	19083

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in mantle cell lymphoma blastoid variant, non-small cell lung cancers and adenocarcinoma tumoral   amplification --over   associated with reduced levels of CDKN1B and an aggressive clinical course in multiple myeloma tumoral   amplification --over   in breast cancer tumoral     --over   of CKS1B or SKP2 contributes to increased p27(Kip1) turnover, cell proliferation, and a poor prognosis in many tumor types tumoral   amplification     in cutaneous squamous cell carcinoma with aggressive clinical behaviour tumoral   amplification     is a high-risk factor in myeloma tumoral     --over   in Retinoblastoma (RB) tissue, compared with adjacent retina tissue

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   therapeutic strategies aimed at abolishing CKS1B function may hold promise for the treatment of high-risk myeloma for which effective therapies are currently lacking cancer skin   Several drugs targeting CKS1B have been reported and may be useful for treating patients with cutaneous squamous cell carcinoma and CKS1B amplifications cancer     target for cancer treatment cancer eye   CKS1B represents a potential research target in the development of therapeutics for RB

ANIMAL & CELL MODELS