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FLASH GENE

Symbol

TRIB3

contributors: mct/npt/pgu - updated : 16-08-2013

HGNC name	tribbles homolog 3 (Drosophila)
HGNC id	16228

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast, colon and lung cancer constitutional     --over   observed in the liver, adipose tissue, skeletal muscle, and pancreatic beta-cells of individuals with insulin resistance and/or T2DM

Susceptibility

to glucose intolerance, type 2 diabete (T2DM)

Variant & Polymorphism other	R84 variant is associated with early-onset T2D
	polymorphism (rs2295490/Q84R) in exon 2 of the pseudokinase-encoding gene tribbles 3 (TRIB3) is associated with an increased risk for T2DM

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS