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FLASH GENE
Symbol FSTL1 contributors: mct/pgu - updated : 24-05-2016
HGNC name follistatin-like 1
HGNC id 3972
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in synovial tissues from rheumatoid arthritis (RA) patients
constitutional     --over  
in the myocardium in response to AKT1-induced hypertrophic growth and myocardial stress, including pressure overload, ischemia-reperfusion, and myocardial infarction
constitutional     --over  
in skeletal muscle in response to hypertrophic signals and ischemic injury, both of which will stimulate blood vessel growth
constitutional     --over  
with FSTL3 in heart failure but returned to normal after recovery
constitutional     --over  
protects against the development of cardiac hypertrophy and heart failure following pressure overload
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serum FSTL1 levels may thus serve as a serological inflammatory marker of disease activity in RA patients
  • Therapy target
    ANIMAL & CELL MODELS
  • endochondral bone development, limb patterning as well as patterning of the axial skeleton are perturbed in the absence of Fstl1 in mice
  • Fstl1-deficient mice displayed a reduction in transverse aortic constriction (TAC)-induced AMP-activated protein kinase (AMPK) activation in heart, whereas Fstl1 overexpression led to increased myocardial AMPK activation under these conditions