Symbol
| FSTL1
| contributors: mct/pgu - updated : 24-05-2016
|
HGNC name
| follistatin-like 1
|
HGNC id
| 3972
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
|  
|  
| --over
|  
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in synovial tissues from rheumatoid arthritis (RA) patients | constitutional
|  
|  
| --over
|  
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in the myocardium in response to AKT1-induced hypertrophic growth and myocardial stress, including pressure overload, ischemia-reperfusion, and myocardial infarction | constitutional
|  
|  
| --over
|  
|
in skeletal muscle in response to hypertrophic signals and ischemic injury, both of which will stimulate blood vessel growth | constitutional
|  
|  
| --over
|  
|
with FSTL3 in heart failure but returned to normal after recovery | constitutional
|  
|  
| --over
|  
|
protects against the development of cardiac hypertrophy and heart failure following pressure overload | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| serum FSTL1 levels may thus serve as a serological inflammatory marker of disease activity in RA patients | |
| Therapy target
| | |
| endochondral bone development, limb patterning as well as patterning of the axial skeleton are perturbed in the absence of Fstl1 in mice | |
Fstl1-deficient mice displayed a reduction in transverse aortic constriction (TAC)-induced AMP-activated protein kinase (AMPK) activation in heart, whereas Fstl1 overexpression led to increased myocardial AMPK activation under these conditions |
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