Symbol
| SRSF1
| contributors: mct - updated : 20-06-2023
|
HGNC name
| serine/arginine-rich splicing factor 1
|
HGNC id
| 10780
|
corresponding disease(s)
|
IDHSC
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
in dorsolateral prefontal cortex of schizophrenic patient | tumoral
|  
|  
| --over
|  
|
in lung and colon cancers | tumoral
|  
| amplification
|  
|  
|
in some breast tumors | tumoral
|  
|  
| --low
|  
|
in newly diagnosed acute myeloid leukemia | constitutional
|  
|  
| --low
|  
|
results in the disorganization of nuclear speckle components | tumoral
|  
|  
| --over
|  
|
in glioma tissues and cell lines | constitutional
|  
|  
| --low
|  
|
in T cells from patients with the autoimmune disease systemic lupus erythematosus (SLE), and low SRSF1 levels inversely correlate with disease severity | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| represents a potential prognostic biomarker for glioma therapy | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
potential target for cancer therapy | cancer | brain | glioma/neuroblstoma | |
represents a potential target for glioma therapy |
| | |
| critical role of an Srsf1-mediated posttranscriptional regulatory mechanism in the mouse oocyte meiotic prophase I program |