Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SRSF1 contributors: mct - updated : 20-06-2023
HGNC name serine/arginine-rich splicing factor 1
HGNC id 10780
ASSOCIATED DISORDERS
corresponding disease(s) IDHSC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in dorsolateral prefontal cortex of schizophrenic patient
tumoral     --over  
in lung and colon cancers
tumoral   amplification    
in some breast tumors
tumoral     --low  
in newly diagnosed acute myeloid leukemia
constitutional     --low  
results in the disorganization of nuclear speckle components
tumoral     --over  
in glioma tissues and cell lines
constitutional     --low  
in T cells from patients with the autoimmune disease systemic lupus erythematosus (SLE), and low SRSF1 levels inversely correlate with disease severity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • represents a potential prognostic biomarker for glioma therapy
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for cancer therapy
    cancerbrainglioma/neuroblstoma
    represents a potential target for glioma therapy
    ANIMAL & CELL MODELS
  • critical role of an Srsf1-mediated posttranscriptional regulatory mechanism in the mouse oocyte meiotic prophase I program