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FLASH GENE

Symbol

NUF2

contributors: mct/npt - updated : 01/10/2008

HGNC name	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
HGNC id	14621

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lung cancer tumoral     --over   in colorectal and gastric cancers (Kaneko 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	suppression of NUF2 or NDC80 activity and/or inhibition of the NUF2-NDC80 complex formation could be a promising therapeutic target for treatment of lung cancers

ANIMAL & CELL MODELS