Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CASP8AP2

contributors: mct/pgu - updated : 22-01-2016

HGNC name	caspase 8 associated protein 2
HGNC id	1510

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric carcinoma tissues tumoral     --low   low expression of CTBP2 and CASP8AP2 correlated with poor outcome and predicted risk of relapse in pediatric BCP-ALL (B cell precursor acute lymphoblastic leukemia)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a promising prognostic indicator in pediatric acute lymphoblastic leukemia (PMID;
	methylation within the CASP8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker for drug resistance in cancer cells (
Therapy target
	System Type Disorder Pubmed cancer     methylation within the CASP8AP2 promoter correlates with the development of drug resistance and might serve as a treatment target for drug resistance in cancer cells

ANIMAL & CELL MODELS