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FLASH GENE
Symbol CASP8AP2 contributors: mct/pgu - updated : 22-01-2016
HGNC name caspase 8 associated protein 2
HGNC id 1510
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in gastric carcinoma tissues
tumoral     --low  
low expression of CTBP2 and CASP8AP2 correlated with poor outcome and predicted risk of relapse in pediatric BCP-ALL (B cell precursor acute lymphoblastic leukemia)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is a promising prognostic indicator in pediatric acute lymphoblastic leukemia (PMID;
  • methylation within the CASP8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker for drug resistance in cancer cells (
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    methylation within the CASP8AP2 promoter correlates with the development of drug resistance and might serve as a treatment target for drug resistance in cancer cells
    ANIMAL & CELL MODELS