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Symbol NUP98 contributors: mct/pgu - updated : 05-06-2015
HGNC name nucleoporin 98kDa
HGNC id 8068
corresponding disease(s) AMLT2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
t(6;11)(q24.1;p15.5) resulting in a NUP98-CCDC28A fusion in acute megakaryoblastic leukemia
tumoral fusion      
fused with HOXD11 in t(5;11)(q35;p15.5) in acute myeloid leukemia
tumoral fusion      
fused with TOP1 in t(11;20)(p15;q11) in therapy related myelodysplastic syndrome, and with HOXA13 int (7;11) (p15;p15)
tumoral fusion      
fused with WHSC1L1 in t(8;11) (p11.2-p15) in acute myeloid leukemia, with ADD3 in t(10;11)(q25;p15) in T-cell acute lymphoblastic leukemia
tumoral fusion      
with DDX10 in de novo or therapy related myeloid malignancies,with HOXD13 or FN1 in translocation t(2;11) (q35;p15) or t(2;11) (q31;p15) in acute myelomonocytic leukemia with inv11(p15-q22)
tumoral fusion      
with PMX1 in translocation t(1;11) (q23;p15),with RAP1GDS1 in t(4;11)(q21;p15) in T cell acute lymphocitic leukemia,with PSIP1 in t (9;11) (p22;p15) in acute myeloid leukemia
tumoral fusion      
to KDM5A in acute lymphoblastic leukemia
tumoral     --over  
of NUP98-HOXA9 represses myeloid-specific gene transcription, thereby contributing to differentiation block in leukemogenesis
tumoral fusion      
NUP98-HOXD13 (NHD13) fusion in patients with myelodysplastic syndrome (MDS) and acute nonlymphocytic leukemia (ANLL)
tumoral   translocation    
t(3;11)(q12;p15)/NUP98-LNP1 fusion transcript in acute myeloid leukemia
tumoral fusion      
NUP98/NSD1 identifies a previously unrecognized group of young acute myeloid leukemia with a distinct HOX gene expression pattern
tumoral fusion      
POU1F1 is a fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15) (
tumoral fusion      
of NUP98 to KDM5A (t(11;15)(p15;q35)in acute megakaryoblastic leukemia (AMKL)
Variant & Polymorphism
Candidate gene
Therapy target