Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCNAB2 contributors: shn - updated : 28-02-2024
HGNC name potassium voltage-gated channel, shaker-related subfamily, beta member 2
HGNC id 6229
ASSOCIATED DISORDERS
corresponding disease(s) DEL1P36
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
can contribute to the Brugada electrocardiographic pattern
Susceptibility to epilepsia
Variant & Polymorphism
Candidate gene for seizures in del1p36 syndrome, primary gene or modifier
Marker
  • can be exploited as a predictive biomarker for evaluating prognosis in Lung adenocarcinoma (LUAD)
  • Therapy target
    SystemTypeDisorderPubmed
    tumor  
    potential new target and pharmacological candidate to be considered in the development of clinical therapeutics for acromegaly
    cancerlung 
    possible immunotherapeutic target in Lung adenocarcinoma (LUAD)
    ANIMAL & CELL MODELS
  • Kvbeta2-null mice have reduced life spans, occasional seizures, and cold swim-induced tremors (
  • mice deleted for KCNAB2 leads to deficits in associative learning and memory, a reduction in the slow afterhyperpolarization following a burst of action potentials and a concomitant increase in neuronal excitability in projection neurons in the lateral nucleus of the amygdala (