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FLASH GENE

Symbol

APOM

contributors: mct - updated : 24-01-2020

HGNC name	apolipoprotein M
HGNC id	13916

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in patients with type 2 diabetes mellitus constitutional     --low   plasma APOM levels were reduced in patients with chronic kidney disease (CKD) stages 3-5D as compared to patients with CKD stages 1 + 2 and controls tumoral     --over   mRNA levels in the colorectal cancer tissues were significantly increased in the patients with lymph node metastasis tumoral     --low   in hepatocellular carcinoma tissues

Susceptibility

to venous thromboembolism (VTE)

Variant & Polymorphism	APOM rs805297 was significantly associated with higher risk of VTE recurrence in male but not in female patients

Candidate gene
Marker	potential for APOM/S1P as biomarkers for inflammation, sepsis and nephropathy
Therapy target

ANIMAL & CELL MODELS

lack of Apom in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity