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FLASH GENE
Symbol DTNBP1 contributors: mct - updated : 20-01-2010
HGNC name dystrobrevin binding protein 1
HGNC id 17328
ASSOCIATED DISORDERS
corresponding disease(s) HPS7 , SCZD3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in dorsolateral prefrontal cortex and hippocampus of schizophrenic patients
Susceptibility
  • to schizophrenia (rs1011313)
  • to intelligence variation
  • to bipolar disorder
  • Variant & Polymorphism SNP
  • influencing intelligence variation
  • association of schizophrenia with SNPs at the 3' end of DTNBP1
  • haplotype increasing the risk of bipolar disorder
  • Candidate gene candidate gene for SCZD3
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sandy (sdy) mice that express no dysbindin, owing to a deletion of the DTNBP1 gene showed behavioral abnormalities such as reduced activity, heightened anxiety-like response, and deficits in social interaction, memory, and learning