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FLASH GENE

Symbol

MIOX

contributors: mct/npt - updated : 15-04-2020

HGNC name	myo-inositol oxygenase
HGNC id	14522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   drives the progression of renal tubulo-interstitial injury in diabetes constitutional     --over   in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy

Susceptibility

to Type 1 diabetes mellitus

Variant & Polymorphism other	polymorphism (rs761745) in the promoter region of MIOX gene may be associated with the development of T1D

Candidate gene
Marker	MIOX levels were higher in gestational diabetes mellitus (GDM) cases so, it may be have a role in myo-inositol catabolism
	potential use of MIOX as a kidney-specific enzyme in the early diagnosis of acute kidney injury (AKI)
	concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of diabetic nephropathy (DN)
Therapy target

ANIMAL & CELL MODELS

	expression of MIOX was increased at both the mRNA and protein levels in the kidney of rats with diabetic nephropathy
	in tubules of diabetic mice, increased MIOX expression and mitochondrial fragmentation and defective autophagy were observed