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Symbol MIOX contributors: mct/npt - updated : 15-04-2020
HGNC name myo-inositol oxygenase
HGNC id 14522
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
drives the progression of renal tubulo-interstitial injury in diabetes
constitutional     --over  
in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy
Susceptibility to Type 1 diabetes mellitus
Variant & Polymorphism other
  • polymorphism (rs761745) in the promoter region of MIOX gene may be associated with the development of T1D
  • Candidate gene
  • MIOX levels were higher in gestational diabetes mellitus (GDM) cases so, it may be have a role in myo-inositol catabolism
  • potential use of MIOX as a kidney-specific enzyme in the early diagnosis of acute kidney injury (AKI)
  • concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of diabetic nephropathy (DN)
  • Therapy target
  • expression of MIOX was increased at both the mRNA and protein levels in the kidney of rats with diabetic nephropathy
  • in tubules of diabetic mice, increased MIOX expression and mitochondrial fragmentation and defective autophagy were observed