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FLASH GENE
Symbol ZPR1 contributors: mct - updated : 30-05-2017
HGNC name zinc finger protein 259
HGNC id 13051
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in patients with severe SMA
constitutional     --low  
causing reduced number of microtubules, responsible for axon retraction, and neurodegeneration
constitutional     --low  
it is possible that the reduced ZPR1 expression observed in SMA patients may contribute to the severity of disease because the primary defect in SMA is the loss of spinal motor neurons
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Zpr1 stimulates neurite growth and rescues axonal growth defects in SMN-deficient spinal cord neurons from SMA mice