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FLASH GENE
Symbol THOC1 contributors: mct/npt - updated : 06-01-2015
HGNC name THO complex 1
HGNC id 19070
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
common in non-small cell lung cancer and may have prognostic significance in subgroups of patients (Yang 2008)
tumoral     --over  
in breast cancer and expression levels correlate with tumor size and metastatic potential(depletion of Thoc1 protein (pThoc1) in cancer cell lines compromises cell proliferation) (Li 2007)
tumoral     --over  
in ovarian and lung tumors
constitutional     --over  
can inhibit cell proliferation, induce G2/M cell cycle arrest and promote apoptosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is a functionally relevant molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may provide a novel molecular target for cancer therapy
    cancerlung 
    may be used as a novel therapeutic target for human lung cancer treatment
    ANIMAL & CELL MODELS
  • murine Thoc1 deletion disrupts homeostasis within the small intestine but does not have detectable effects in other epithelial tissues such as the related mucosa of the large intestine
  • Thoc1 deletion prevents prostate cancer progression in mice, but has little effect on normal tissue