Symbol
| TREM2
| contributors: mct/ - updated : 03-05-2016
|
HGNC name
| triggering receptor expressed on myeloid cells 2
|
HGNC id
| 17761
|
corresponding disease(s)
|
PLOSL2
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --other
|  
|
in Cerebrospinal fluid soluble TREM2 correlates with aging | constitutional
|  
|  
|  
| loss of function
|
alters acute macrophage distribution and improves recovery after Traumatic brain injury (TBI) | |
Susceptibility
|
to late-onset Alzheimer disease (AD) |
Variant & Polymorphism
other
| rs75932628 (encoding R47H), showed highly significant association with Alzheimer disease |
|
|
|
|
Candidate gene
Marker
Therapy target
| | | |
| Trem2-deficient (TREM2(-/-)) mice had defective clearance of myelin debris and more axonal pathology, resulting in impaired clinical performances compared to wild-type (WT) mice |