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FLASH GENE
Symbol TREM2 contributors: mct/ - updated : 03-05-2016
HGNC name triggering receptor expressed on myeloid cells 2
HGNC id 17761
ASSOCIATED DISORDERS
corresponding disease(s) PLOSL2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
in Cerebrospinal fluid soluble TREM2 correlates with aging
constitutional       loss of function
alters acute macrophage distribution and improves recovery after Traumatic brain injury (TBI)
Susceptibility to late-onset Alzheimer disease (AD)
Variant & Polymorphism other rs75932628 (encoding R47H), showed highly significant association with Alzheimer disease
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Trem2-deficient (TREM2(-/-)) mice had defective clearance of myelin debris and more axonal pathology, resulting in impaired clinical performances compared to wild-type (WT) mice