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FLASH GENE
Symbol RSF1 contributors: mct - updated : 24-10-2018
HGNC name remodeling and spacing factor 1
HGNC id 18118
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
is associated with advanced clinical stage and lymph node metastasis in ovarian clear cell carcinoma
constitutional     --over  
promoted chromosomal instability as evidenced by increased karyotypic abnormalities and DNA copy number alterations in otherwise chromosomally stable cells
tumoral     --over  
in non-small cell lung cancer
constitutional       loss of function
RSF1 deficiency did not result in any neuropathological abnormalities, but prevented neural apoptosis triggered by excessive DNA strand breaks during neurogenesis
tumoral     --over  
in 41.1 p 100 of hepatocellular carcinoma correlated with poor overall survival
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serves as a novel tumor marker in hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    RSF1 gene-transduced dendritic cells may be a potential adjuvant immunotherapy for ovarian cancer in clinical applications
    cancerlung 
    candidate therapeutic target in lung cancer
    ANIMAL & CELL MODELS