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FLASH GENE
Symbol PTGES2 contributors: SGE/npt/pgu - updated : 27/04/2010
HGNC name prostaglandin E synthase 2
HGNC id 17822
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal cancer
tumoral     --over  
overexpressed in glioma, in both low- and high-grade tumors
Susceptibility to type 2 diabetes
Variant & Polymorphism SNP
  • R298H polymorphism was significantly associated with impaired glucose tolerance and type 2 diabetes
  • a marginal but significant influence of PTGES2 R298H SNP on body mass index
  • Candidate gene
  • may play a role in colorectal cancer progression
  • Marker
    Therapy target
    ANIMAL & CELL MODELS