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FLASH GENE

Symbol

CPM

contributors: mct - updated : 24-04-2020

HGNC name	carboxypeptidase M
HGNC id	2311

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in several tumor tissues tumoral     --over   in renal clear cell carcinomas tumoral   amplification     in well-differentiated liposarcomas/atypical lipomatous tumor

Susceptibility

to silicosis

Variant & Polymorphism other	rs12812500 variant of the CPM gene may increase silicosis susceptibility

Candidate gene
Marker	CPM is a novel marker in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
	identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors
Therapy target
	System Type Disorder Pubmed diabete type 2   therapeutic target in insulin resistance

ANIMAL & CELL MODELS